Classic Paper from Peppas Research is the Most Highly Cited Paper in the History of the "Journal of Controlled Release"
The Journal of Controlled Release was published in 1984 by Elsevier. Since it inception it has been the official organ of the Controlled Release Society. Its first two editors were Jorge Heller (previously of APS) and Jan Feijen (of Twente University). Among 4,367 papers, the two most cited papers in this journal are the well-known contributions of Phil Ritger and Nicholas Peppas that introduced the exponential equation for the analysis of relaxation and diffusion-controlled release behavior from swellable and non-swellable delivery systems. The paper "A simple equation for description of solute release. II: Fickian and anomalous release from swellable devices", published in 1987, in volume 5, pp. 37-42, has 565 citations and is ranked first among all papers of the journal, while the first part of the same work "A simple equation for description of solute release. I: Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs", published also in 1987, in volume 5, pp. 23-36, has 468 citations and is ranked second. The exponential equation was actually introduced in a simple form in a 1985 publication in Pharmaceutica Acta Helvetiae by Prof. Peppas, but it was in these two 1987 papers out of the MS thesis of Phil Ritger that the full mathematical analysis for all geometries was presented.
Most Cited Article in the History of the "International Journal of Pharmaceutics" is Based on Peppas Research
It was announced recently that the most cited publication among 9,180 papers in the 31-year history of the International Journal of Pharmaceutics is the paper "Mechanisms of Solute Release from Porous Hydrophilic Polymers" co-authored by Drs Richard Korsmeyer (now Global Head of Licensing, Worldwide Pharmaceutical Sciences, Pfizer Global Research & Development), Robert Gurny and Eric Doelker (now professors at the University of Geneva), Pierre Buri (now retired professor at the same University) and Professor Nicholas Peppas. Published in January 1983, this paper has become a "classic" in the field and the most cited publication of this premier international pharmaceutical journal published by Elsevier. Published in Volume 15, pages 25-25, this paper reported the earliest studies on the mechanisms of Fickian and anomalous transport of drugs from glassy, hydrophilic polymers. Most of the work was done in collaborative research by Purdue and University of Geneva investigators and especially when Dr Korsmeyer had visited the University of Geneva in 1981. Dr Peppas was on sabbatical leave at the University of Geneva in September-December 1982. This paper has received 316 citations.
Most Cited Article in the History of the journal "Drug Development and Industrial Pharmacy" is Based on Peppas Research
It was also announced recently that the most cited publication among 3,878 papers in the 33-year history of the international journal Drug Development and Industrial Pharmacy is the paper "Pharmaceutical and Medical Aspects of Bioadhesive Systems for Drug Administration" co-authored by Drs Dominique Duchêne (now retired professor of the University of Paris-Sud), Frederic Touchard of Paris and Professor Nicholas Peppas. Published in February 1988, this paper has become the most cited publication of this premier international pharmaceutical journal. Published in Volume 14, pages 283-318, this paper reported on fundamental studies on mucoadhesion, performed while Dr Peppas was on sabbatical leave at the University of Paris-Sud in July-December 1986. This paper has received 148 citations.
Six Current Papers Authored by Researchers in the Peppas Lab are in the List of "Top Twenty Five Hottest Articles" of Science DirectTM
A recent analysis of the "Top Twenty Five Hottest Articles" as reported by the Science Direct TM revealed that six articles co-authored by present or past laboratory researchers and based on their work here at UT, are in the list of "Hottest Papers"
After almost three years in the list, Jay Blanchette's paper on "Nanoparticle and Targeted Systems for Cancer Therapy" published in Advanced Drug Delivery Reviews, Volume 56, Issue 11, 1 September 2004, Pages 1649-1659 with Professor Lisa Brannon-Peppas is still No 13 in the list! Jay (a 2005 PhD of the lab) is now an Assistant Professor in the Biomedical Program of the Chemical Engineering Department of the University of South Carolina.
Nikhil Kavimandan's article on "Nanoscale Analysis of Protein and Peptide Absorption: Insulin Absorption Using Complexation and pH-Sensitive Hydrogels as Delivery Vehicles" published with Prof. Peppas in the European Journal of Pharmaceutical Sciences, Volume 29, Issue 3-4, 1 November 2006, Pages 183-197 is No 10 in the list. Nikhil (a 2005 PhD of the lab) is now with Novartis in New Jersey.
Don Owens' article on "Opsonization, Biodistribution and Pharmacokinetics of Polymeric Nanoparticles" published with Prof. Peppas in the International Journal of Pharmaceutics, Volume 307, Issue 1, 1 January 2006, Pages 93-102 is ranked No 10. Don (a 2007 PhD of the lab) is now with ExxonMobil
Mamuru Fukuda's article on "Floating Hot-melt Extruded Tablets for Gastroretentive Controlled Drug Release Systems" published with Professors J. McGinity and Peppas in the Journal of Controlled Release, Volume 115, Issue 2, 1 October 2006, Pages 121-129 is ranked No 13. Mamuru-san is now back in Kyorin Pharmaceutical Co.
Two review articles are also ranked in the first ten hottest articles. The recent review of professor Peppas on "Is the Oral Route Possible for Peptide and Protein Drug Delivery?" published with professor M. Morishita of Hoshi University (Tokyo) in Drug Discovery Today, Volume 11, Issue 19-20, 1 October 2006, Pages 905-910 was ranked No 8. And the review on "Structure and Interactions in Covalently and Ionically Crosslinked Chitosan Hydrogels for Biomedical Applications" published with Prof. R. Gurny of the University of Geneva in the European Journal of Pharmaceutics and Biopharmaceutics, Volume 57, Issue 1, 1 January 2004, Pages 19-34 is still No 6 after 3 1/2 years in the list.
Most Cited Article in the History of the "European Journal of Pharmaceutics and Biopharmaceutics" is Based on Peppas Research
It was also announced recently that the most cited publication in the 52-year history of the European Journal European Journal of Pharmaceutics and Biopharmaceutics (previously known also as Acta Pharmaceutica Technologica) is the paper "Hydrogels in Pharmaceutical and Medical Applications" authored by Drs Petr Bures (now with Bayer in Pittsburgh, PA), Bill Leobandung (now in Jakarta, Indonesia), Dr Hideki Ichikawa (now a professor at Kobe-Gakuin University in Kobe, Japan) and Professor Nicholas Peppas. Published in July 2000, this paper has become the most cited publication of this premier European pharmaceutical journal. Published in Volume 50, pages 27-46, this paper was commissioned by the Chief editor of the journal to commemorate the journal's fiftieth issue. This paper has received 343 citations.
